Publications

Publications

Search Kornfeld Lab publications in PubMed

Search for Kornfeld Lab in Wormbase

Casorla-Perez LA, Guennoun R, Cubillas C, Peng B, Kornfeld K, Wang D. Orsay Virus Infection of Caenorhabditis elegans Is Modulated by Zinc and Dependent on Lipids. J Virol. 2022 Nov 23;96(22):e0121122. doi: 10.1128/jvi.01211-22. Epub 2022 Nov 7. PMID: 36342299

Egan BM, Scharf A, Pohl F, Kornfeld K. Control of aging by the renin-angiotensin system: a review of C. elegans, Drosophila, and mammals. Front Pharmacol. 2022 Sep 14;13:938650. doi: 10.3389/fphar.2022.938650. eCollection 2022. PMID: 36188619 

Strong R, Miller RA, Cheng CJ, Nelson JF, Gelfond J, Allani SK, Diaz V, Dorigatti AO, Dorigatti J, Fernandez E, Galecki A, Ginsburg B, Hamilton KL, Javors MA, Kornfeld K, Kaeberlein M, Kumar S, Lombard DB, Lopez-Cruzan M, Miller BF, Rabinovitch P, Reifsnyder P, Rosenthal NA, Bogue MA, Salmon AB, Suh Y, Verdin E, Weissbach H, Newman J, Maccchiarini F, Harrison DE. Lifespan benefits for the combination of rapamycin plus acarbose and for captopril in genetically heterogeneous mice. Aging Cell. 2022 Dec;21(12):e13724. doi: 10.1111/acel.13724. Epub 2022 Sep 30. PMID: 36179270

Tan CH, Kornfeld K. Zinc is an intracellular signal during sperm activation in Caenorhabditis elegans. Development. 2021 Nov 1;148(21):dev199836. doi: 10.1242/dev.199836. Epub 2021 Nov 5. PMID: 34739028

Earley BJ, Cubillas C, Warnhoff K, Ahmad R, Alcantar A, Lyon MD, Schneider DL, Kornfeld K. Cadmium hijacks the high zinc response by binding and activating the HIZR-1 nuclear receptor. Proc Natl Acad Sci U S A. 2021 Oct 19;118(42):e2022649118. doi: 10.1073/pnas.2022649118. PMID: 34649987

Scharf A, Pohl F, Egan BM, Kocsisova Z, Kornfeld K. Reproductive Aging in Caenorhabditis elegans: From Molecules to Ecology. Front Cell Dev Biol. 2021 Sep 16;9:718522. doi: 10.3389/fcell.2021.718522. eCollection 2021. PMID: 34604218

Earley BJ, Mendoza AD, Tan CH, Kornfeld K. Zinc homeostasis and signaling in the roundworm C. elegans. Biochim Biophys Acta Mol Cell Res. 2021 Jan;1868(1):118882. doi: 10.1016/j.bbamcr.2020.118882. Epub 2020 Oct 2. PMID: 33017595

Murphy JT, Liu H, Ma X, Shaver A, Egan BM, Oh C, Boyko A, Mazer T, Ang S, Khopkar R, Javaheri A, Kumar S, Jiang X, Ory D, Mani K, Matkovich SJ, Kornfeld K, Diwan A. Simple nutrients bypass the requirement for HLH-30 in coupling lysosomal nutrient sensing to survival. PLoS Biol. 2019 May 14;17(5):e3000245. doi: 10.1371/journal.pbio.3000245. eCollection 2019 May. PMID: 31086360

Kumar S, Egan BM, Kocsisova Z, Schneider DL, Murphy JT, Diwan A, Kornfeld K. Lifespan Extension in C. elegans Caused by Bacterial Colonization of the Intestine and Subsequent Activation of an Innate Immune Response. Dev Cell. 2019 Apr 8;49(1):100-117.e6. doi: 10.1016/j.devcel.2019.03.010. PMID: 30965033

Kocsisova Z, Kornfeld K, Schedl T. Rapid population-wide declines in stem cell number and activity during reproductive aging in C. elegans. Development. 2019 Apr 23;146(8). pii: dev173195. doi: 10.1242/dev.173195. PMID: 30936182

Kocsisova Z, Mohammad A, Kornfeld K, Schedl T. Cell Cycle Analysis in the C. elegans Germline with the Thymidine Analog EdU. J Vis Exp. 2018 Oct 22;(140). doi: 0.3791/58339. PMID: 30394383

Zhao Y, Tan CH, Krauchunas A, Scharf A, Dietrich N, Warnhoff K, Yuan Z, Druzhinina M, Gu SG, Miao L, Singson A, Ellis RE, Kornfeld K. The zinc transporter ZIPT-7.1 regulates sperm activation in nematodes. PLoS Biol. 2018 Jun 7;16(6):e2005069. doi: 10.1371/journal.pbio.2005069. eCollection 2018 Jun. PMID: 29879108

Kocsisova Z, Kornfeld K, Schedl T. Cell cycle accumulation of the proliferating cell nuclear antigen PCN-1 transitions from continuous in the adult germline to intermittent in the early embryo of C. elegans. BMC Dev Biol. 2018 May 30;18(1):12. doi: 10.1186/s12861-018-0171-7. PMID: 29848313

Dietrich N, Schneider DL, Kornfeld K. A pathway for low zinc homeostasis that is conserved in animals and acts in parallel to the pathway for high zinc homeostasis. Nucleic Acids Res. 2017 Nov 16;45(20):11658-11672. doi: 10.1093/nar/gkx762. PMID: 28977437

Warnhoff K, Roh HC, Kocsisova Z, Tan CH, Morrison A, Croswell D, Schneider DL, Kornfeld K. The Nuclear Receptor HIZR-1 Uses Zinc as a Ligand to Mediate Homeostasis in Response to High Zinc. PLoS Biol. 2017 Jan 17;15(1):e2000094. doi: 10.1371/journal.pbio.2000094. eCollection 2017 Jan. PMID: 28095401

Dietrich N, Tan CH, Cubillas C, Earley BJ, Kornfeld K. Insights into zinc and cadmium biology in the nematode Caenorhabditis elegans. Arch Biochem Biophys. 2016 Dec 1;611:120-133. doi: 10.1016/j.abb.2016.05.021. Epub 2016 May 31. Review. PMID: 27261336

Kumar S, Dietrich N, Kornfeld K. Angiotensin Converting Enzyme (ACE) Inhibitor Extends Caenorhabditis elegans Life Span. PLoS Genet. 2016 Feb 26;12(2):e1005866. doi: 10.1371/journal.pgen.1005866. eCollection 2016. PMID: 26918946

Warnhoff K, Kornfeld K. New links between protein N-terminal acetylation, dauer diapause, and the insulin/IGF-1 signaling pathway in Caenorhabditis elegans. Worm. 2015 Mar 11;4(2):e1023498. doi: 10.1080/21624054.2015.1023498. PMID: 26435887

Leight ER, Murphy JT, Fantz DA, Pepin D, Schneider DL, Ratliff TM, Mohammad DH, Herman MA, Kornfeld K. Conversion of the LIN-1 ETS Protein of Caenorhabditis elegans from a SUMOylated Transcriptional Repressor to a Phosphorylated Transcriptional Activator. Genetics. 2015 Mar;199(3):761-75. doi: 10.1534/genetics.114.172668. Epub 2015 Jan 7. PMID: 25567989

Roh HC, Dimitrov I, Deshmukh K, Zhao G, Warnhoff K, Cabrera D, Tsai W, Kornfeld K.
A modular system of DNA enhancer elements mediates tissue-specific activation of transcription by high dietary zinc in C. elegans. Nucleic Acids Res. 2015 Jan;43(2):803-16. doi: 10.1093/nar/gku1360. Epub 2014 Dec 30. PMID: 25552416

Kumar S, Kocsisova Z, Kornfeld K. Keep on laying eggs Mama, RNAi my reproductive aging blues away. PLoS Genet. 2014 Dec 4;10(12):e1004808. doi: 10.1371/journal.pgen.1004808. eCollection 2014 Dec. PMID: 25474201

Warnhoff K, Murphy JT, Kumar S, Schneider DL, Peterson M, Hsu S, Guthrie J, Robertson JD, Kornfeld K. The DAF-16 FOXO transcription factor regulates natc-1 to modulate stress resistance in Caenorhabditis elegans, linking insulin/IGF-1 signaling to protein N-terminal acetylation. PLoS Genet. 2014 Oct 16;10(10):e1004703. doi: 10.1371/journal.pgen.1004703. eCollection 2014 Oct. PMID: 25330323

Pickett CL, Dietrich N, Chen J, Xiong C, Kornfeld K. Mated progeny production is a biomarker of aging in Caenorhabditis elegans. G3 (Bethesda). 2013 Dec 9;3(12):2219-32. doi: 10.1534/g3.113.008664. PMID: 24142929

Roh HC, Collier S, Deshmukh K, Guthrie J, Robertson JD, Kornfeld K.
ttm-1 encodes CDF transporters that excrete zinc from intestinal cells of C. elegans and act in a parallel negative feedback circuit that promotes homeostasis. PLoS Genet. 2013 May;9(5):e1003522. doi: 10.1371/journal.pgen.1003522. Epub 2013 May 23. PMID: 23717214

Pickett CL, Kornfeld K. Age-related degeneration of the egg-laying system promotes matricidal hatching in Caenorhabditis elegans. Aging Cell. 2013 Aug;12(4):544-53. doi: 10.1111/acel.12079. Epub 2013 May 2. PMID: 23551912

Roh HC, Collier S, Guthrie J, Robertson JD, Kornfeld K. Lysosome-related organelles in intestinal cells are a zinc storage site in C. elegans. Cell Metab. 2012 Jan 4;15(1):88-99. doi: 10.1016/j.cmet.2011.12.003. PMID: 22225878

Hughes SE, Huang C, Kornfeld K. Identification of mutations that delay somatic or reproductive aging of Caenorhabditis elegans. Genetics. 2011 Sep;189(1):341-56. doi: 10.1534/genetics.111.130450. Epub 2011 Jul 12. PMID: 21750263

Murphy JT, Bruinsma JJ, Schneider DL, Collier S, Guthrie J, Chinwalla A, Robertson JD, Mardis ER, Kornfeld K. 2011. Histidine protects against zinc and nickel toxicity in Caenorhabditis elegans. PLoS Genet. 2011 Mar;7(3):e1002013. Epub 2011 Mar 24.

Liu Z, Schneider DL, Kornfeld K, Kopan R.2010. Simple copy number determination with reference query pyrosequencing (RQPS) .Cold Spring Harb Protoc. 2010 Sep 1;2010(9):pdb.prot5491. doi: 10.1101/pdb.prot5491.

Johnson, K.G., Kornfeld K., 2010. The CRAL/TRIO and GOLD domain protein TAP-1 regulates RAF-1 activation. Dev. Biol. doi:10.1016/j.ydbio.2010.03.003. (Abstract)

Davis, D. E., Roh, H. C., Deshmukh, K., Bruinsma, J. J., Schneider, D. L., Guthrie, J., Robertson, J. D., and Kornfeld K., 2009. The Cation Diffusion Facilitator Gene cdf-2 Mediates Zinc Metabolism in Caenorhabditis elegans. Genetics. 182, 1015-33. (Abstract)

Collins, J.J., Evason, K., Pickett, C.L., Schneider, D.L., and Kornfeld, K. 2008. The Anticonvulsant Ethosuximide Disrupts Sensory Function to Extend C. elegans Lifespan. PLoS Genetics, 4(10):e1000230. (Abstract)

Bruinsma, J.J., Schneider D., Davis, D., and K. Kornfeld. 2008. Identification of mutations in Caenorhabditis elegans that cause resistance to high levels of dietary zinc and analysis using a genome-wide map of single-nucleotide polymorphisms scored by pyrosequencing. Genetics, 179: 811-828. (Abstract)

Evason, K., Collins, J.J., Huang, C., Hughes, S., and K. Kornfeld. 2008. Valproic acid extends C. elegans lifespan. Aging Cell, 7: 305-317. (Abstract)

Collins, J.J., C. Huang, S. Hughes and K. Kornfeld. 2007. The measurement and analysis of age-related changes in Caenorhabditis elegans. WormBook, ed. The C. elegans Research Community, WormBook, http://www.wormbook.org. (Abstract)

Hughes, S., K. Evason, C. Xiong and K. Kornfeld. 2007. Genetic and pharmacological factors thatinfluence reproductive aging in nematodes. PLoS Genetics, 3(2): 254-265. (Abstract)

Collins, J.J., K. Evason and K. Kornfeld. 2006. Pharmacology of delayed aging and extended lifespan of Caenorhabditis elegans. Experimental Gerontology 41: 1032-1039. (Abstract)

Wagmaister, J. A., G.R. Miley, C.A. Morris, J.E. Gleason, L.M. Miller, K. Kornfeld and D. M.
Eisenmann. 2006. Identification of cis-regulatory elements from the C. elegans Hox gene lin-39 required for embryonic expression and for regulation by the transcription factors LIN-1, LIN-31, and LIN-39. Developmental Biology 297: 550-565. (Abstract)

Evason, K., and K. Kornfeld. 2006. Effects of anticonvulsant drugs on lifespan. Archives of Neurology, 63: 491-496. (Abstract)

Goldstein, J., D. Glossip, S. Nayak and K. Kornfeld. 2006. The CRAL/TRIO and GOLD domain protein CGR-1 promotes induction of vulval cell fates in Caenorhabditis elegans and interacts genetically with the Ras signaling pathway. Genetics, 172: 929-942. (Abstract)

Evason, K., C. Huang, I. Yamben, D.F. Covey and K. Kornfeld. 2005. Anticonvulsant medications extend worm life-span. Science 307: 258-262. (Abstract)

Leight, E., D. Glossip, and K. Kornfeld. 2005. Sumoylation of LIN-1 promotes transcriptional repression and inhibition of vulval cell fates. Development 132: 1047-1056. (Abstract)

Miley, G., D. Fantz, D. Glossip, X. Lu, R. Saito,, R. Palmer, T. Inoue, S. van den Heuvel, P. Sternberg, and K. Kornfeld. 2004. Identification of residues of the Caenorhabditis elegans LIN-1 ETS domain that are necessary for DNA binding and regulation of vulval cell fates. Genetics 167: 1697-1709. (Abstract)

Huang, C., C. Xiong and K. Kornfeld. 2004. Measurements of age-related changes of physiological processes that predict life span of Caenorhabditis elegans. Proc. Natl. Acad. Sci. USA., 101: 
8084-8089. (Abstract)

Harding, A., V. Hsu, K. Kornfeld and J.F. Hancock. 2003. Identification of residues and domains of Raf important for function in vivo and in vitro. J. Biol. Chem. 278: 45519-45527. (Abstract)

Bruinsma, J. J., T. Jirakulaporn, A. J. Muslin and K. Kornfeld. 2002. Zinc ions and cation diffusion facilitator proteins regulate Ras-mediated signaling. Developmental Cell 2: 567-578. (Abstract)

Hsu, V., Zobel, C., Lambie, E., Schedl. T. and K. Kornfeld. 2002. Caenorhabditis elegans lin-45 raf is essential for larval viability, fertility and the induction of vulval cell fates. Genetics 160: 481-492. (Abstract)

Fantz, D.A., D. Jacobs, D. Glossip and K. Kornfeld. 2001. Docking sites on substrate proteins direct extracellular-signal regulated kinase to phosphorylate specific residues. J. Biol. Chem. 276: 
27256-27265. (Abstract)

Jakubowski, J., and K. Kornfeld. 1999. A local, high-density, single-nucleotide polymorphism map used to clone Caenorhabditis elegans cdf-1. Genetics 153: 743-752. (Abstract)

Jacobs, D., D. Glossip, H. Xing, A.J. Muslin and K. Kornfeld. 1999. Multiple docking sites on substrate 
proteins form a modular system that mediates recognition by ERK MAP kinase. Genes & Development 
13:163-175. (Abstract)

Jacobs, D., G.J. Beitel, S.G Clark. H.R. Horvitz and K. Kornfeld. 1998. Gain-of-function mutations in the 
C. elegans lin-1 ETS gene identify a C-terminal regulatory domain phosphorylated by ERK MAP kinase. 
Genetics 149: 1809-1822. (Abstract)

Kornfeld, K. 1997. Vulval development in Caenorhabditis elegans. Trends in Genetics 13: 55-61. (Abstract)

Xing, H., K. Kornfeld and A.J. Muslin. 1997. The protein kinase KSR interacts with 14-3-3 protein and Raf. 
Current Biology 7: 294-300. (Abstract)

Kornfeld, K., D.B. Hom and H.R. Horvitz. 1995. The ksr-1 gene encodes a novel protein kinase involved in 
Ras-mediated signaling in C. elegans. Cell 83: 903-913. (Abstract)

Kornfeld, K., K.-L. Guan and H.R. Horvitz. 1995. The Caenorhabditis elegans gene mek-2 is required for vulval induction and encodes a protein similar to the protein kinase MEK. Genes & Development 9: 756-768.(Abstract)

Lackner, M.R., K. Kornfeld, L.M. Miller, H.R. Horvitz and S.K. Kim. 1994. A MAP kinase homolog, mpk-1, is involved in ras-mediated induction of vulval cell fates in Caenorhabditis elegans. Genes & Development 8: 160-173. (Abstract)